"Czech Airlines" restored Friday the Skopje-Prague flight, which was cancelled four years ago.
The Skopje-Prague flight will operate twice a week, with a third flight introduced by the end of June.
Ticket prices start at EUR 75 for a one-way ticket and EUR 144 for a return ticket.
"I am satisfied over the flight's restoration. The package includes morning flights from Skopje and night flights from Prague, which gives visitors maximum use of their stay in the Czech Republic. This will suit both tourists and business passengers", said Jan Toth, Director of Commerce, Alliances and Marketing at Czech Airlines.
TAV Macedonia director Zoran Krstevski said the Prague flight should increase economic and cultural exchange between the two countries, more Czech tourists and rise in cargo transport.